Opioid action is due to both equally very low affinity binding from the parent compound and better affinity binding of your O-demethylated metabolite M1 to μ-opioid receptors. In animal styles, M1 is approximately six instances additional strong than tramadol in manufacturing analgesia and two hundred instances additional powerful in μ-opioid https://nielsl135oqp8.blogoscience.com/profile