Anaphylaxis: Anaphylaxis has become noted with codeine, one of the substances in promethazine HCl and codeine phosphate oral Answer. The opioid antagonists, naloxone and nalmefene, are certain antidotes for respiratory melancholy resulting from opioid overdose. For clinically substantial respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. https://akornpromethazinecodeine25678.blog2learn.com/80116724/top-guidelines-of-akorn-codeine