Below, we clearly show that conolidine, a purely natural analgesic alkaloid used in common Chinese drugs, targets ACKR3, therefore delivering more proof of a correlation among ACKR3 and pain modulation and opening different therapeutic avenues with the procedure of chronic soreness. Tabernaemontana divaricata Conolidine is undoubtedly an indole alkaloid. https://anthonyp369upl8.wikifordummies.com/user