If a father or mother on the proband is understood to provide the pathogenic variant recognized in the proband, the danger into the sibs of inheriting the pathogenic variant is 50%. As a result of minimized penetrance, sibs who inherit the pathogenic variant might or might not produce aHUS (see https://heatpumphire22097.blog2freedom.com/32844027/top-guidelines-of-air-handling-unit-ahu-hire