Sedative medicines such as benzodiazepines or associated medications: The concomitant utilization of opioids with sedative medicines such as benzodiazepines or related medications boosts the chance of sedation, respiratory despair, coma and Dying thanks to additive CNS depressant impact. The dose and duration of concomitant use needs to be constrained (see https://kevina689piz2.jts-blog.com/profile